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Featured Tribute peptide synthesizer publication

Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides


Two polar hinges for cyclization of peptides have been developed, leading to bicyclic peptides and cyclized peptides with improved solubility and biological activity. The new hinges also likely impose different conformations on peptides, and this makes them attractive reagents for the synthesis of combinatorial libraries of (bi)cyclic peptides 
for incorporation on scaffolds to afford protein mimics.

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H. van de Langemheen, V. Korotkovs, J. Bijl, C. Wilson, S. S. Kale, C. Heinis, R. M. J. Liskamp, ChemBioChem 2017,18, 387